IJMS | Free Full-Text | A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (HTT)
Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice - ScienceDirect
FAN1 nuclease processes and pauses on disease-associated slipped-DNA repeats: Mechanism against repeat expansions | bioRxiv
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FAN1 nuclease processes and pauses on disease-associated slipped-DNA repeats: Mechanism against repeat expansions | bioRxiv
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease | Journal of Medicinal Chemistry
FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats | Science Advances
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CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset - ScienceDirect
FAN1 nuclease activity affects CAG expansion and age at onset of Huntington's disease | bioRxiv
Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice - ScienceDirect
A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome | Nature Biomedical Engineering
Frontiers | Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat Diseases
Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset | Nature Neuroscience
Cell Type Specific CAG Repeat Expansion and Toxicity of Mutant Huntingtin in Human Striatal and Cerebellar Cell Types | bioRxiv
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Spinocerebellar ataxias: prospects and challenges for therapy development | Nature Reviews Neurology
A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes - eBioMedicine
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PDF) Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice
Biomedicines | Free Full-Text | CAG Repeat Instability in the Peripheral and Central Nervous System of Transgenic Huntington’s Disease Monkeys
